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Nitric
Oxide Discovery
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AMERICANS WIN NOBEL IN
MEDICINE Associated Press, Tuesday, October 13, 1998
Three Americans won the Nobel
Prize in medicine Monday for discovering that the body uses nitric oxide gas
to make blood vessels relax and widen – a finding that helped lead to Viagra
and could also pay off in treatments for heart disease. In addition, it has triggered research that could lead to new
treatments for cancer and septic shock. The prize announced in Sweden, went to Robert F. Furchgott, Louis J. Ignarro and
Dr. Ferid Murad. Furchgott, 82, is
a pharmacologist at the State University of New York Health Science Center at
Brooklyn; Ignarro, 57, is at the University of
California at Los Angeles; and Murad, 62, is at the
University of Texas Medical School in Houston. They will split the $978,000 prize. Cells in the body make nitric oxide, which, paradoxically, is
also an air pollutant in auto exhaust.
It is different from nitrous oxide, better known as laughing gas. The researchers discovered that the body’s
own nitric oxide acts as a signal, telling blood vessels to dilate. That, in turn, lowers blood pressure. The work already has inspired a treatment for dangerously high
blood pressure in the lungs of infants.
Babies breathe the gas. “Now, finally this discovery can be put to use in treatment of numerous
pathologies,” said Ignarro, who was reached in
Naples, Italy. “The future of
pharmacology is in the creation of a superaspirin that will be fundamental in the prevention
of heart attacks, of cardiovascular disease, of arteriosclerosis.” Scientists were surprised when Furchgott
and Ignarro reported the findings in 1986. Nitric oxide was the first gas to be
identified as a signal in the body. “It was a sensation that this simple common air pollutant…could
exert important functions” in animals and people, said the Karolinska Institute in Stockholm, which awards the
prize. The gas makes blood vessels dilate by relaxing the vessels’
smooth muscles. It can help trigger
erection of the penis the same way, because the relaxation lets blood flow
in. Viagra was designed to work by
blocking an enzyme that interferes with nitric oxide’s effect. The prize-winning work contributed “a small piece of
information” to the development of Viagra, said Mariann
Caprino, spokeswoman for Viagra maker Pfizer Inc. Dr. Valentin Fuster,
president of the American Heart Association, called the nitric oxide
discovery “one of the most important in the history of cardiovascular
medicine.” By showing the gas played an important role in the body, the
researchers set off a cascade of studies that discovered other key things the
gas does, Fuster said. The wide-ranging results may pay off in new treatments for: Atherosclerosis, a thickening of artery walls due to fatty
deposits. Nitric oxide has turned out
to be one of the body’s main weapons against atherosclerosis, said Dr.
Jonathan Stamler of the Duke University Medical
Center and the Howard Hughes Medical Institute. Septic shock, the dangerous drop in blood pressure caused by
white cells pumping out too much nitric oxide in response to infections. Drugs that reduce the levels of active
nitric oxide are being studied in people. Cancer, White cells use nitric oxide to defend against tumors,
and scientists are studying whether they can harness the substance’s
anti-cancer ability. Murad, who worked
independently of the other winners, called the Nobel announcement “a
delightful surprise.” Furchgott, reached at his home on New York’s Long Island,
said: “I’m very pleased. I truly
wasn’t sure I’d ever get an award like this.
I wasn’t sure that I deserved it.” Murad discovered in
1977 that nitroglycerin and related artery-widening compounds act by
releasing nitric oxide. Furchgott later concluded that cells in the inner lining
of blood vessels secrete some unknown substance that makes vessels
dilate. Ignarro,
working with Furchgott and independently, concluded
this unknown signal is nitric oxide. Alfred Nobel, a Swedish industrialist and inventor of dynamite,
endowed the Nobel Prizes in his will.
In later life, Nobel’s doctor told him to take nitroglycerin – one of
the ingredients in dynamite – for heart trouble. “However, it would take 100 years until it was clarified that
nitroglycerin acts by releasing nitric oxide gas,” the Karolinska
Institute said. |
Far Infrared Ray Dome (FIR Dome) Benefits
Infrared photons produce enzymes
that activate macrophages, which help eliminate damaged and diseased tissue. Macrophages work on a cellular
level. Nitric oxide
is released and expands capillaries.
It also increases circulation and carries toxins to the lymph system
and out of the body. Why is this infrared system
unique? It uses infrared radiant
energy to directly penetrate the body’s tissues to a depth of over 1 ½”. Its energy output is tuned to correspond so
closely to the body’s own radiant energy that our bodies absorb close to 93%
of the infrared waves that reach our skin. One of the reasons FIR has beneficial results in a variety of illnesses is the ability of FIR waves to remove toxins, which are often at the core of many health problems. Numerous toxins are stored in our bodies. Toxic gases may be encapsulated by clusters of water. Where these toxins are accumulated, blood circulation is blocked and cellular energy is impaired. When a 10 micron FIR wave is applied to these large water molecules, the water begins to vibrate, which reduces the ion bonds of the atoms which are holding together the molecules of water. As the breakdown of the water molecules occurs, encapsulated gases and other toxic materials are released. |
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